The Red Hook area is very crowded with private moorings and is subject to frequent ferry wakes. However if you are going to / from BVi, it is obviously convenient. Long Bay, Charlotte Amalie always has room to anchor and has access to dinghy dock, bus, etc but is right downtown. To still have access to services but quieter would be Elephant bay or Honeymoon bay, the two bays on the west side of Water Island, but they can also be crowded with local moorings.