Land based or on a boat?
Have only done boat based trips and love Deshaies on the west coast. Beautiful little town and great anchorage, home of the BBC TV series 'Death in Paradise'. Also, if on a boat, Isles des Saintes off the southern tip of Guadeloupe is one of my favourite places on earth.
Some knowledge of French is a help but, as everywhere in the world, if you want to buy something and they want to sell something, you'll get by. Google translate can of course help enormously.